One of the most prolific scientists in an emerging area of cancer research involving what is sometimes called the “dark matter” of the human genome has parlayed his decades-long pursuit of cancer remedies into a research empire: He has received more than $86 million in federal grants as a principal investigator and, by his own count, more than 60 awards. However, over the last several years a tide of allegations have been made concerning data falsification and other scientific misconduct. Concerns about falsified data in the scientific literature run far deeper as cases of fraud can reverberate through whole fields of research.

A former Texas Tech University researcher, who was convicted of mishandling harassment complaints and cheating the university out of its share of clinical-research money, was sentenced last week to two years in prison and a $15,000 fine.

The professoriate is a gatekeeper, determining a student's first exposure to ethical standards, traditions. Many observers of contemporary academic culture have documented cases if irresponsible and unethical behavior within the professoriate. Examples include lateness for class, use of vulgarity in scholarly forums, showing favouritism among students, improper use of campus funds, plagiarism, sexual liaisons with students, failure to properly perform administrative duties, and, most basic, unwillingness to uphold the value of truth in teaching and research.

The Bush administration proposed guidelines last month that would let research institutions decide whether to restrict researchers' financial interests in studies involving human subjects, and whether such interests should be reported to the research volunteers.